Apell HJ 2019
Finding Na,K-ATPase II – From Fluxes to Ion Movements.
Substantia 3:19-41
[pdf]

Apell HJ 2018
Finding Na,K-ATPase I - From Cell to Molecule.
Substantia 2:17-28
[pdf]

Vishnyakova VYe, Tashkin VYu, Terentjev AO, Apell HJ, Sokolov VS 2018
Binding of Potassium Ions in Access Channel at Cytoplasmic Side of Na+,K+-ATPase.
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 12:344-351; in Russian: Biologicheskie Membrany 35:376-383
[KOPS]

Apell HJ 2017
Mechanistic principles of ion transport in the Na,K-ATPase.
Russ. J. Electrochemistry 53:237-247; in Russian: Elektrokhimiya 53(3):270-281
[KOPS]

Jiang Q, Garcia A, Han M, Cornelius F, Apell HJ, Khandelia H, Clarke RJ 2017
Electrostatic stabilization plays a central role in the autoinhibitory regulation of the Na+,K+-ATPase.
Biophys. J. 112:288-299
[PubMed]

Apell HJ, Hitzler T, Schreiber G 2017
Modulation of the Na,K-ATPase by magnesium ions.
Biochemistry 56:1005-1016
[PubMed]

Apell HJ 2017
Subtle mutation, far-reaching effects.
J. Gen.Physiol. 149:969-973
[PubMed]

Apell HJ, Damnjanovic B 2016
Assaying P-type ATPases Reconstituted in Liposomes. In: P-Type ATPases: Methods and Protocols (M. Bublitz, ed.) - Methods in Molecular Biology, Vol. 1377, Springer Science+Business Media, New York, pp. 127-156
[PubMed]

Estrada Mallarino L, Fan E, Odermatt M, Müller M, Lin M, Liang J, Heinzelmann M, Fritsche F, Apell HJ, Welte W 2015
TtOmp85, a ß-barrel assembly protein, functions by barrel augmentation
Biochemistry 54:844-852
[PubMed]

Gradinaru R, Apell HJ 2015
Probing the extracellular access channel of the Na,K-ATPase
Biochemistry 54:2508-2519
[ACS Publications]

Tashkin VYu, Gavrilchik AN, Ilovaisky AI, Apell HJ, Sokolov VS 2015
Electrogenic Binding of Ions at the Cytoplasmic Side of the Na+,K+-ATPase
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 9:92-99
[pdf-File]

Mishra N, Haviv H, Kirchner C, Habeck M, Nadav N, Eisenstein M, Apell HJ, Karlish SJD 2015
Kinetic effects of human FXYD1 and phosphomimetic mutants on purified human Na,K-ATPase
J. Chem. Biol. 290:28746-28759, DOI: 10.1074/jbc.M115.687913
[PubMed]

Apell HJ, Sokolov VS 2015
Study of Pump Activity Using Black Lipid Membranes. In: Pumps, Channels and Transporters: Methods of Functional Analysis (R.J. Clarke, M.A.A. Khalid eds.), Chemical Analysis – A Series of Monographs on Analytical Chemistry and its Applications, Vol. 183, John Wiley & Sons, Hoboken, pp. 23-49
[Wiley]

Damnjanovic B, Apell HJ 2014
Role of protons in the pump cycle of KdpFABC investigated by time-resolved kinetic experiments
Biochemistry 53:3218-3228
[ACS Publications]

Apell HJ 2014
Does the sodium pump have secret levels?
Biophysical Journal 106:2552-2554
[Biophysical Journal]

Damnjanovic B, Apell HJ 2014
KdpFABC reconstituted in E. coli lipid vesicles: substrate dependence of the transport rate
Biochemistry 53:5674-5682
[ACS Publications]

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R 2014
A Novel tumor necrosis factor–mediated mechanism of direct epithelial sodium channel activation
American Journal of Respiratory and Critical Care Medicine 190:522-532
[AJRCCM]

Tashkin VYu, Shcherbakov AA, Apell HJ, Sokolov VS 2013
The competition transport of sodium and protons in cytoplasmic access channel of the Na+,K+-ATPase
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 7:113-121
[pdf-File]

Clarke RJ, Catauro M, Rasmussen HH, Apell HJ 2013
Quantitative calculation of the role of the Na+,K+-ATPase in thermogenesis
Biochim Biophys Acta 1827:1205-1212
[PubMed]

Damnjanovic B, Weber A, Potschies M, Greie JC, Apell HJ 2013
Mechanistic analysis of the pump cycle of the KdpFABC P-type ATPase
Biochemistry 52:5563-5576
[ACS Publications]

Cirri E, Kirchner C, Becker S, Katz A, Karlish SJ, Apell HJ 2013
Surface charges of the membrane crucially affects regulation of the Na,K-ATPase by phospholemman (FXYD1)
J Membr Biol. 246:967-979
[PubMed]

Garcia A, Frey NAS, Karimi K, Liu C, Apell HJ, Rasmussen HH, Clarke RJ 2013
Extracellular allosteric Na+ binding to the Na+,K+-ATPase in cardiac myocytes
Biophys. J. 105:2695-2705
[PubMed]

Garcia A, Rasmussen HH, Apell, HJ, Clarke RJ 2012
Kinetic comparison of heart and kidney Na+,K+-ATPases
Biophys J 103:677-688
[PubMed]

Myers SL, Cornelius F, Apell, HJ, Clarke RJ 2011
Kinetics of K+ occlusion by the phosphoenzyme of the Na+,K+-ATPase
Biophys J 100:70-79
[KOPS]

Apell HJ, Benz, G, Sauerbrunn, D 2011
Proton diet for the sodium pump
Biochemistry 50:409-418
[ACS Publications]

Mishra HK, Peleg Y, Cirri E, Belogus T, Lifshitz Y, Voelker DR, Apell HJ, Garty H, Karlish SJ 2011
FXYD proteins stabilize Na,K-ATPase: amplification of specific phosphatidylserine-protein interactions
J Biol Chem 286:9699-9712
[PubMed]

Cirri E, Katz A, Mishra HK, Belogus T, Lifshitz Y, Garty H, Karlish SJ, Apell HJ 2011
Phospholemman (FXYD1) raises the affinity of the human a1ß1 isoform of Na,K-ATPase for Na ions
Biochemistry 50:3736-3748
[ACS Publications]

Hianik T, Rybar P, Krivanek R, Petrikova M, Roudna M, Apell HJ 2011
Specific volume and compressibility of bilayer lipid membranes with incorporated Na,K-ATPase
Gen Physiol Biophys 30:145-153
[PubMed]

Fibich A, Apell HJ 2011
Kinetics of luminal proton binding to the SA Ca-ATPase
Biophys J 101:1896-1904 30:145-153
[PubMed]

Khalid M, Fouassier G, Apell HJ, Cornelius F, Clarke RJ 2010
Interaction of ATP with the Phosphoenzyme of the Na+,K+-ATPase
Biochemistry 49:1248-1258
[ACS Publications]

Witzke A, Lindner K, Munson K, Apell HJ 2010
Inhibition of the gastric H,K-ATPase by clotrimazole
Biochemistry 49:4524-4532
[ACS Publications]

Grishanin KO, Tashkin V, Lenz AA, Apell HJ, Sokolov VS 2010
Involvement of protons in the ion transport cycle of Na,K-ATPase
Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology 4:431-436
[pdf-File]

Habeck M, Cirri E, Katz A, Karlish SJ, Apell HJ 2009
Investigation of Electrogenic Partial Reactions in Detergent-Solubilized Na,K-ATPase
Biochemistry 48:9147-9155
[ACS Publications]

Pilotelle-Brunner A, Matthews JM, Cornelius F, Apell HJ, Sebban P, Clarke RJ 2008
ATP Binding Equilibria of the Na,K-ATPase
Biochemistry 47:13103-13114
[pdf-File]

Bartolommei G, Devaux N, Tadini-Buoninsegni F, Moncelli MR, Apell HJ 2008
Effect of Clotrimazole on the Pump Cycle of the Na,K-ATPase
Biophys. J. 95:1813-1825
[pdf-File]

Fibich A, Jüngst C, Apell HJ 2008
Properties of the SR Ca-ATPase in an Open Microsomal Membrane Preparation
The Open Biochem. J. 2:91-99
[pdf-File]

Sokolov VS, Scherbakov AA, Lenz AA, Chizmadzhev YuA, Apell HJ 2008
Electrogenic transport of sodium ions in cytoplasmic and extracellular ion access channels of Na⁺, K⁺-ATPase probed by admittance measurement technique
Biochemistry (Moscow) Supplement Series A 2:161-180
[pdf-File]

Fibich A, Janko K and Apell HJ 2007
Kinetics of proton binding to the SR Ca-ATPase in the E₁ state
Biophys. J. 93:3092-3104
[pdf-File]

Sokolov VS, Sokolenko EA, Filinsky DV, Ermakov YuA, Lopina OD, and Apell HJ 2007
Electrostatic potentials arising due to adsorption of Na⁺,K⁺-ATPase-containing membrane fragments on bilayer lipid membrane
Biologicheskie Membrany 24:259-272 (in Russian)

Shanmugavadivu B, Apell HJ, Meins T, Zeth K, Kleinschmidt JH 2007
Correct folding of the beta-barrel of the human membrane protein VDAC requires a lipid bilayer
J Mol Biol. 368:66-78
[PubMed]

Clarke RJ, Apell HJ, Kong BY 2007
Allosteric Effect of ATP on Na(+),K(+)-ATPase Conformational Kinetics
Biochemistry 46:7034-7044
[pdf-File]

Pocanschi CL, Dahmane T, Gohon Y, Rappaport F, Apell HJ, Kleinschmidt JH, Popot JL 2006
Amphipathic Polymers: Tools To Fold Integral Membrane Proteins to Their Active Form
Biochemistry 45:13954-13961
[pdf-File]

Harmel N, Apell HJ 2006 Palytoxin-induced Effects on Partial Reactions of the Na,K-ATPase
J Gen Physiol. 128(1):103-118
[PubMed]

Amoroso S, Agon VV, Starke-Peterkovic T, McLeod MD, Apell HJ, Sebban P, Clarke RJ. 2006 Photochemical Behavior and Na⁺,K⁺-ATPase Sensitivity of Voltage-sensitive Styrylpyridinium Fluorescent Membrane Probes.
Photochem Photobiol. 82(2):495-502
[pdf-File]

Pocanschi CL, Apell HJ, Puntervoll P, Hogh B, Jensen HB, Welte W, Kleinschmidt JH. 2006 The major outer membrane protein of Fusobacterium nucleatum (FomA) folds and inserts into lipid bilayers via parallel folding pathways.
J Mol Biol. 355(3):548-61
[pdf-File]

Ayuyan AG, Sokolov VS, Lenz AA, Apell HJ. 2006 Effect of chaotropic anions on the sodium transport by the Na,K-ATPase.
Eur Biophys J. 35(3):247-54
[PubMed]

Stimac R, Kerek F, Apell HJ. 2005 Mechanism of the Na,K-ATPase inhibition by MCS derivatives.
J Membr Biol. 205(2):89-101
[PubMed]

Peinelt C, Apell HJ. 2005 Kinetics of Ca²⁺ binding to the SR Ca-ATPase in the E₁ state.
Biophys J. 89(4):2427-33
[pdf-File]

Diller A, Vagin O, Sachs G, Apell HJ. 2005 Electrogenic partial reactions of the gastric H,K-ATPase.
Biophys J. 88(5):3348-59
[PubMed]

Killig F, Stark G, Apell HJ. 2004 Photodynamic inactivation of the Na,K-ATPase occurs via different pathways.
J Membr Biol. 200(3):133-44
[PubMed]

Apell HJ. 2004 How do P-type ATPases transport ions?
Bioelectrochemistry 63(1-2):149-56
[PubMed]

Peinelt C, Apell HJ. 2004 Time-resolved charge movements in the sarcoplasmatic reticulum Ca-ATPase.
Biophys J. 86(2):815-24
[PubMed]

Apell HJ. 2003 Structure-function relationship in P-type ATPases--a biophysical approach.
Rev Physiol Biochem Pharmacol. 150:1-35
[PubMed]

Stimac R, Kerek F, Apell HJ. 2003 Macrocyclic carbon suboxide oligomers as potent inhibitors of the Na,K-ATPase.
Ann N Y Acad Sci. 986:327-9
[PubMed]

Peinelt C, Apell HJ. 2003 Time-resolved partial reactions of the SR Ca-ATPase investigated with a fluorescent styryl dye.
Ann N Y Acad Sci. 986:325-6
[PubMed]

Ayuyan AG, Sokolov VS, Apell HJ. 2003 Salt effects on the kinetics of the electrogenic Na⁺ transport in the Na,K-ATPase.
Ann N Y Acad Sci. 986:252-4
[PubMed]

Sokolov VS, Lenz AA, Apell HJ. 2003 Negative changes of the membrane capacitance due to electrogenic Na transport by the Na,K-ATPase.
Ann N Y Acad Sci. 986:229-31
[PubMed]

Clarke RJ, Humphrey PA, Lupfert C, Apell HJ, Cornelius F. 2003 Kinetic investigations of the mechanism of the rate-determining step of the Na⁺,K⁺-ATPase pump cycle.
Ann N Y Acad Sci. 986:159-62
[PubMed]

Apell HJ. 2003 Toward an understanding of ion transport through the Na,K-ATPase.
Ann N Y Acad Sci. 986:133-40
[PubMed]

Kerek F, Stimac R, Apell HJ, Freudenmann F, Moroder L. 2002 Characterization of the macrocyclic carbon suboxide factors as potent Na,K-ATPase and SR Ca-ATPase inhibitors.
Biochim Biophys Acta. 1567(1-2):213-20
[PubMed]

Apell HJ, Diller A. 2002 Do H⁺ ions obscure electrogenic Na⁺ and K⁺ binding in the E₁ state of the Na,K-ATPase?
FEBS Lett. 532(1-2):198-202
[PubMed]

Masilamani M, Apell HJ, Illges H. 2002 Purification and characterization of soluble CD21 from human plasma by affinity chromatography and density gradient centrifugation.
J Immunol Methods. 270(1):11-8
[PubMed]

Humphrey PA, Lupfert C, Apell HJ, Cornelius F, Clarke RJ. 2002 Mechanism of the rate-determining step of the Na⁺,K⁺-ATPase pump cycle.
Biochemistry. 41(30):9496-507
[PubMed]

Pedersen M, Roudna M, Beutner S, Birmes M, Reifers B, Martin HD, Apell HJ. 2002 Detection of charge movements in ion pumps by a family of styryl dyes.
J Membr Biol. 185(3):221-36
[PubMed]

Peinelt C, Apell HJ. 2002 Kinetics of the Ca²⁺, H⁺, and Mg²⁺ interaction with the ion-binding sites of the SR Ca-ATPase.
Biophys J. 82(1 Pt 1):170-81
[PubMed]

Sokolov VS, Ayuyan AG, Apell HJ. 2001 Assignment of charge movements to electrogenic reaction steps of Na,K-ATPase by analysis of salt effects on the kinetics of charge movements.
Eur Biophys J. 30(7):515-27
[PubMed]

Lupfert C, Grell E, Pintschovius V, Apell HJ, Cornelius F, Clarke RJ. 2001 Rate limitation of the Na⁺,K⁺-ATPase pump cycle.
Biophys J. 81(4):2069-81
[PubMed]

Apell HJ, Karlish SJ. 2001 Functional properties of Na,K-ATPase, and their structural implications, as detected with biophysical techniques.
J Membr Biol. 180(1):1-9
[PubMed]

Schneeberger A, Apell HJ. 2001 Ion selectivity of the cytoplasmic binding sites of the Na,K-ATPase: II. Competition of various cations.
J Membr Biol. 179(3):263-73
[PubMed]>

Shainskaya A, Schneeberger A, Apell HJ, Karlish SJ. 2000 Entrance port for Na⁺ and K⁺ ions on Na⁺,K⁺-ATPase in the cytoplasmic loop between trans-membrane segments M6 and M7 of the alpha subunit. Proximity Of the cytoplasmic segment of the beta subunit.
J Biol Chem. 275(3):2019-28
[PubMed]