Publications

Publications in 2023

  1. Alessio Butera, Lena Smirnova, Elisa Ferrando-May, Thomas Hartung, Thomas Brunner, Marcel Leist, Ivano Amelio. Deconvoluting gene and environment interactions to develop an “epigenetic score meter” of disease. EMBO Molecular Medicine e18208. 2023.
  2. Ilinca Suciu, David Pamies, Roberta Peruzzo, Petra H. Wirtz, Lena Smirnova, Giorgia Pallocca, Christof Hauck, Mark T.D. Cronin, Jan G. Hengstler, Thomas Brunner, Thomas Hartung, Ivano Amelio, Marcel Leist. G x E interactions as a basis for toxicological uncertainty. Springer. Archives of Toxicology. doi.org/10.1007/s00204-023-03500-9. June 2023.
  3. Ilio Vitale, … Thomas Brunner, …, Lorenzo Galluzzi. Apoptotic cell death in disease - Current understanding of the NCCD 2023. Nature,Cell Death & Differentiation. (2023) 30:1097-1154. April 2023.
  4. Asma Ahmed, Cindy Reinhold, Eileen Breunig, Truong San Phan, Lea Dietrich, Feodora Kostadinova, Corinne Urwyler, Verena M. Merk, Mario Noti, Israel Toja da Silva, Konstantin Bode, Fatima Nahle, Anna Pia Plazzo, Julia Koerner, Regula Stuber, Constantin Menche, Eva Karamitopoulou, Henner F. Farin, Kenneth J. Gollob, Thomas Brunner. Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. Molecular Oncology. doi:10.1002/1878-0261.13414. February 2023  
  5. Verena M. Merk, Leonie Grob, Achim Fleischmann, Thomas Brunner. Human lung carcinomas synthesize immunoregulatroy glucocorticoids. Nature. Genes & Immunity.doi.org/10.1038/s41435-023-00194-y. January 2023

Publications in 2022

  1. Svenja Michalek, Thomas Goj, Anna Pia Plazzo, Blerim Marovca, Beat Bornhauser, Thomas Brunner. LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance. EMBO reports. e54195. June 2022
  2. Carina Arnold, Philipp Demuth, Nina Seiwert, Simon Wittmann, Kerstin Boengler, Birgit Rasenberger, Markus Christmann, Magdalena Huber, Thomas Brunner, Michael Linnebacher. The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner. AACR Journals, Molecular Cancer Therapeutics 2022;21:100-12. January 2022.
  3. Zirui Lü, Xiaona Li, Kebin Li, Paola Ripani, Xiaomeng Shi, Fengrong Xu, Mopei Wang, Liangren Zhang, Thomas Brunner, Ping Xu, Yan Niu. Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes. Elsevier. Biochemical Pharmacology. 197(2022) 114913. January 2022.

Publications in 2021

  1. Julius Bogomolovas, Jennifer Fleming, Barbara Franke, Bruno Manso, Bernd Simon, Alexander Gasch, Marija Markovic, Thomas Brunner, Ralph Knöll, Ju Chen, Siegfried Labeit, Martin Scheffner, Christine Peter, and Olga Mayans. Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere. EMBO reports. 22: e48018. 2021.
  2. Noti M, Brunner T. Microbiome-host-immune crosstalk: mining the microbiome: a treasure trove waiting to be unlocked. Genes & Immunity. Doi.org/10.1038/s41435-021-00148-2. 2021.
  3. Jiso A, Demuth P, Bachowsky M, Haas M, Seiwert N, Heylmann D, Rasenberger B, Christmann M, Dietrich L, Brunner T, Riyanti, Schäberle T F, Plubrukarn A, Fahrer J. Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-Type and Mutant Colorectal Cancer. Cancers. Doi.org/10.3390. 13, 3282. 2021
  4. Merk V M, Phan T S, Brunner T. Regulation of Tissue Immune Responses by Local Glucocorticoids at Epithelial Barriers and Their Impact on Interorgan Crosstalk. Frontiers in Immunology. 12:672808. 2021.
  5. Phan T S, Schink L, Mann J, Merk V M, Zwicky P, Mundt S, Simon D, Kulms D, Abraham S, Legler D F, Noti M, Brunner T. Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids. Science Advances. Cell Biology. 7:eabe0337. 2021.
  6. Phan T S, Brunner T. The versatility of liver X receptors in T cell homeostasis: Location, location, location!. doi.org/10.1084/jem.20202318. 2021.
  7. Michalek S, Brunner T. Nuclear-mitochondrial crosstalk: On the role of the nuclear receptor liver receptor homolog-1 (NR5A2) in the regulation of mitochondrial metabolism, cell survival, and cancer. IUBMB Life 2021; 73:592-610. 2021.

Publications in 2020

  1. Seiwert N, Wecklein S, Demuth P, Hasselwander S, Kemper Talke A., Schwerdtle T, Brunner T, Fahrer J. Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron. Cell Death & Disease. doi.org/10.1038/s41419-020-02950-8. 2020.
  2. Schwaderer J, Phan TS, Glöckner A, Delp J, Leist M, Brunner T, Delgado ME. Pharmacological LRH-1/Nr5a2 inhibition limits proinflammatory cytokine production in macrophages and associated experimental hepatitis. Cell Death & Disease. Open Access. doi.org/10.1038/s41419-020-2348-9. 2020.

Publications in 2019

  1. Ripani P, Delp J, Bode K, Delgado M E, Dietrich L, Betzler V M, Yan N, von Scheven G, Mayer T U, Leist M, Brunner T.Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain.Springer Nature. Oncogene. doi.org/10.1038/s41388-019-1142-6. December 2019.
  2. Seitz C, Huang J, Geiselhöringer AL, Galbani-Bianchi P, Michalek S, Phan TS,
    Reinhold C, Dietrich L, Schmidt C, Corazza N, Delgado E, Schnalzger T, Schoonjans
    K, Brunner T. The orphan nuclear receptor LRH-1/NR5a2 critically regulates T cell
    functions. Sci Adv. 2019 Jul 17;5(7):eaav9732. doi: 10.1126/sciadv.aav9732.
    eCollection 2019 Jul. PubMed PMID: 31328159; PubMed Central PMCID: PMC6636985.
  3. Ahmed A, Schmidt C, Brunner T. Extra-Adrenal Glucocorticoid Synthesis in the
    Intestinal Mucosa: Between Immune Homeostasis and Immune Escape. Front Immunol. 2019 Jun 25;10:1438. doi: 10.3389/fimmu.2019.01438. eCollection 2019. Review. PubMed PMID: 31316505; PubMed Central PMCID: PMC6611402.
  4. Gougeon ML, Schwartz M, Brunner T, Ojcius DM. 130th anniversary of Institut
    Pasteur: celebrating science. Microbes Infect. 2019 Jun 25. pii:
    S1286-4579(19)30070-X. doi: 10.1016/j.micinf.2019.06.010. [Epub ahead of print] PubMed PMID: 31247327.
  5. Bode KJ, Mueller S, Schweinlin M, Metzger M, Brunner T. A fast and simple
    fluorometric method to detect cell death in 3D intestinal organoids.
    Biotechniques. 2019 Jul;67(1):23-28. doi: 10.2144/btn-2019-0023. Epub 2019 Jun
    20. PubMed PMID: 31218886.
  6. Spinnenhirn V, Demgenski J, Brunner T. Death Receptor Interactions With the
    Mitochondrial Cell Death Pathway During Immune Cell-, Drug- and Toxin-Induced
    Liver Damage. Front Cell Dev Biol. 2019 Apr 24;7:72. doi:
    10.3389/fcell.2019.00072. eCollection 2019. Review. PubMed PMID: 31069226; PubMed Central PMCID: PMC6491631.
  7. Gougeon ML, Schwartz M, Brunner T, Ojcius DM. 130th anniversary of Institut
    Pasteur: celebrating science. Genes Immun. 2019 May;20(5):342-343. doi:
    10.1038/s41435-019-0070-3. Epub 2019 Apr 25. PubMed PMID: 31019251.
  8. Streichert K, Seitz C, Hoffmann E, Boos I, Jelkmann W, Brunner T, Unverzagt C,
    Rubini M. Synthesis of Erythropoietins Site-Specifically Conjugated with
    Complex-Type N-Glycans. Chembiochem. 2019 Aug 1;20(15):1914-1918. doi:
    10.1002/cbic.201900023. Epub 2019 Jul 9. PubMed PMID: 30973186.
  9. Phan TS, Merk VM, Brunner T. Extra-adrenal glucocorticoid synthesis at
    epithelial barriers. Genes Immun. 2019 Jan 29. doi: 10.1038/s41435-019-0058-z.
    [Epub ahead of print] PubMed PMID: 30692606.
  10. Delgado ME, Brunner T. The many faces of tumor necrosis factor signaling in
    the intestinal epithelium. Genes Immun. 2019 Jan 28. doi:
    10.1038/s41435-019-0057-0. [Epub ahead of print] PubMed PMID: 30686825.
  11. Ahmed A, Schwaderer J, Hantusch A, Kolho KL, Brunner T. Intestinal
    glucocorticoid synthesis enzymes in pediatric inflammatory bowel disease
    patients. Genes Immun. 2019 Jan 28. doi: 10.1038/s41435-019-0056-1. [Epub ahead
    of print] PubMed PMID: 30686824.
  12. Li J, Koerner J, Basler M, Brunner T, Kirk CJ, Groettrup M. Immunoproteasome
    inhibition induces plasma cell apoptosis and preserves kidney allografts by
    activating the unfolded protein response and suppressing plasma cell survival
    factors. Kidney Int. 2019 Mar;95(3):611-623. doi: 10.1016/j.kint.2018.10.022.
    Epub 2019 Jan 23. PubMed PMID: 30685098.

    

Publications in 2018


  1. Brunner T. Ecto-calreticulin is essential for an efficient immunogenic cell
    death stimulation in mouse melanoma : by Paola Giglio and colleagues, Genes and Immunity, October 4, 2018. Genes Immun. 2019 Jan 4. doi:10.1038/s41435-018-0054-8. [Epub ahead of print] PubMed PMID: 30607011.
  2. Gutbier S, Spreng AS, Delp J, Schildknecht S, Karreman C, Suciu I, Brunner T, Groettrup M, Leist M. Prevention of neuronal apoptosis by astrocytes through thiolmediated stress response modulation and accelerated recovery from proteotoxic stress. Cell Death Differ. 25:2101-2117. 2018
  3. Faletti L, Sandler S, Peintner L, Neumann L, Grabinger T, McNelly S, Merfort I, Huang, CH, Kang, TW, Tschaharganeh D, Brunner T, Maurer U, Lowe S, Zender L, Borner C. TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation. Cell Death Dis. 9:909. 2018.
  4. Huang J, Jia R, Brunner T. Local synthesis of immunosuppressive glucocorticoids in the intestinal epithelium regulates anti-viral immune responses. Cell. Immunol. 2018. Epub ahead
  5. Hantusch A, Rehm M, Brunner T. Counting on Death – Quantitative aspects of Bcl-2 family regulation. FEBS Journal. Doi: 10.1111/bebs. 14516. Epub. 2018.
  6. Hantusch A., Das K.K., Garcia-Saez A.J., Brunner T.*, Rehm M*. Bax retrotranslocation potentiates Bcl-xL’s anti-apoptotic activity and is essential for switch-like transitions between MOMP competency and resistance. Cell Death Dis.9:430. 2018. *Co-senior author
  7. Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A. Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa. J. Am. Chem Soc. 140:2537-2545. 2018
  8. Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, Groettrup M. Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation. Kidney Int. 93:670-680. 2018

Publications in 2017

  1. Pfammatter NS, Luckschander N, Jakob S, Hartnack S, Brunner T, Burgener IA. Horizontal and Vertical Distribution of CD3+ Lymphocytes in the Intestine of Healthy Adult and Neonatal Dogs. Journal of Clinical Gastroenterology and Hepatology ISSN 2575-7733. Vol.1No.3:21. DOI:10.21767/2575-7733.1000021.2017
  2. Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, Groettrup M. Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation. Kidney International. Doi.org/10.1016.j.kint2017.09.023.2017
  3. Haimovici A, Humbert M, Federzoni EA, Shan-Krauer D, Brunner T, Frese S, Kaufmann T, Torbet BE, Tschan MP. PU.1 supportd TRAIL-induced cell death by inhibiting NF-kB-mediated cell ssurvival and inducing DR5 expression. Cell Death Diff. 1-12 .2017
  4. Schwaderer J, Gaiser A.K., Phan T.S., Delgado M.E., Brunner T. Liver receptor homolog-1 (NR5a2) regulates CD95/Fas Ligand transcription and associated T cell effector functions. Cell Death Dis. 8, e2745. 2017
  5. Koerner J, Brunner T, Groettrup M. Inhibition and deficiency of the immunoproteosome subunit LMP7 supress the development and progression of colorectal carcinoma in mice. Oncotarget Epub ahead. 2017
  6. Hantusch A, Brunner T, Frickey T, Rehm M. Bcl-2-Ome – a database and interactive web service for dissecting the Bcl-2 interactome. Cell Death and Differentiation. 24, 192. 2017
  7. Grabinger T, Bode K, Demgenski J, Seitz C, M. Delgado E, Kostadinova F, Reinhold C, Etemadi N, Wilhelm S, Schweinlin M, Hänggi K, Knop J, Hauck C, Walles H, Silke J, Wajant H, Nachbur U, Wong W-L, Brunner T. Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor-mediated Destruction of Intestinal Epithelial Cells. Gastroenterology, 152:867-879. 2017

Publications in 2016

  1. Muenzer P, Tchoupa A K, Klauser B, Brunner T, Putze J, Dobrindt U, Hauck C. Uropathogenic E. coli Expliut CEA to Promote Colonization of the Urogenital Tract Mucosa. 5.-e1005608. PLoS Pathogens. 2016
  2. Hoffmann E, Streichert K Nischan N, Seitz C, Brunner T, Schwagerus S, Hackenberger CPR, Rubini M. Stabilization of bacterially expressed erythropoietin by single site-specific introduction of short branched PEG chains at naturally occurring glycosylation sites. Doi: 10.1039. Royal Society of Chemistry/Molecular BioSystems. 2016

  3. Grabinger T, Delgado E, Brunner T. Analysis of Cell Death Induction in Intestinal Organoids In Vitro. Programmed cell death: methods and protocols / Puthalakath, Hamsa et al. (Hrsg.).-New York, NY: Humana Press, 2016.-(Methods in Molecular Biology; 1419).-S.83-93.-ISBN 978-1-4939-3579-6. 2016

Publications in 2015

  1. Schildknecht S, Pape R, Meiser J, Karreman C, Strittmatter T, Odermatt M, Cirri E, Friemel A, Ringwald M, Pasquarelli N, Ferger B, Brunner T, Marx A, Möller HM, Hiller K, Leist M. Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+. Doi: 10.1089. Volume 23, Number 13. Antioxidants & Redox Signaling 2015
  2. Brockmann A, Bluwstein A, Kögel A, May S, Marx A, Tschan MP, Brunner T. Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation. Doi:10.1038 Cell Death and Disease. 2015
  3. Delgado ME, Grabinger T, Brunner T. Cell death at the intestinal epithelial front line. Doi: 10.1111. the FEBS Journal. 2015
  4. Bouguen G, Dubuquoy P, Desreumaux P, Brunner T, Bertin B. Intestinal steroidogenesis. Steroids 103 64-71. Elsevier. 2015
  5. Chopra M, Brandl A, Siegmund D, Mottok A, Schäfer V, Biehl M, Kraus S, Bäuerlein A, Ritz M, Mattenheimer K, Schwinn S, Seher A, Grabinger T, Einsele H, Rosenwald A, Brunner T, Beilhack A, Wajant H. Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation induced intestinal cell death and reduces GvHD. Doi:10.1182. Blood. 2015

Publications in 2014

  1. Kostadinova F, Schwaderer J, Sebeo V, Brunner T. Why does the gut synthesize glucocorticoids? Informa Healthcare. Doi 10.3109/07853890 932920. 2014
  2. Grabinger T, Luks L, Kostadinova F, Zimerberlin C, Medema JP, Leist M, Brunner T. Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy. Doi:10.1038/cddis.2014.183. Cell Death and Disease. 2014
  3. Brockmann A, Strittmatter T, May S, Stemmer K, Marx A, Brunner T. Structure-Function Relationship of Thiazolide-Induced Apoptosis in Colorectal Tumor Cells. ACS chemical biology. Dx.doi.org/10.1021/cb500209a. 05/2014.
  4. Krug AK, Gutbier S, Zhao L, Pöltl D, Kullmann C, Ivanova V, Förster S, Jagtap S, Meiser J, Leparc G, Schildknecht S, Adam M, Hiller K, Farhan H, Brunner T, Hartung T, Sachinidis A, Leist M. Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP (+). Cell Death Dis. 2014 May 8;5:e1222
  5. Fahrner R, Trochsler M, Corazza N., Graubardt N, Keogh A, Candinas D, Brunner T, Stroka D, Beldi G. Tumor necrosis factor-related apoptosis-inducing ligand on NK cells protects from hapatic ischemia-reperfusion injury. Transplantation. 2014
  6. Tobias Strittmatter, Anette Brockmann, Moritz Pott, Annika Hantusch, Thomas Brunner, and Andreas Marx. Expanding the Scope of Human DNA Polymerase λ and ß Inhibitors. Dx.doi.org/10.1021/cb4007562 ACS chemical biology. 2014

Publications in 2013

  1. Grabinger T, Peterburs P, Brunner T. dsDNA ASCs for caspase 8-mediated apoptosis. Cell Death and Differentiation. Doi:10.1038/cdd. 2013.80. 2013

Publications in 2012

  1. Badmann A, Langsch S, Keogh A, Brunner T, Kaufmann T, Corazza N. TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner. Cell death & Disease. 3:e447. Doi:10.1038/cddis.185. 2012
  2. Kostadinova F, Hostettler N, Bianchi P, Brunner T. Extra-adrenal glucocorticoid synthesis in mucosal tissues and its implication in mucosal immune homeostasis and tumour development. In: “Glucocorticoids: New Recognition of Our Familiar Friend” (open access book). DOI:10.5772/52788. Intech. Chapter 4. ISBN 978-953-51-0872-6. 2012
  3. Sidler D, Renzulli P, Schnoz C, Berger B, Schneider-Jakob S, Flück C, Inderbitzin D, Corazza N, Candinas D, Brunner T.  Colon cancer cells produce immunoregulatory glucocorticoids. OncoImmunology 1:4;529-530. 2012.
  4. Lauer C, Brunner T, Corazza N. The pro-apoptotic Bcl-2 family member Bim plays a central role during the development of virus-induced hepatitis. Journal of Immunologie 188;916-922. 2012.
  5. Hostettler N, Bianchi B, Gennari-Moser C, Kassahn D, Schoonjans K,  Corazza N, Brunner T. Local glucocorticoid production in the mouse lung is induced by immune cell stimulation. Allergy 67:227-234. 2012
  6. Sidler D, Brockmann A, Mueller J, Nachbur U, Corazza N, Renzulli P, Hemphill A, Brunner T. Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles’ heel. Oncogene 31,4095-4106. 2012

Publications in 2011

  1. Badmann A, Keough A, Kaufmann T, Bouillet P, Brunner T, Corazza N. Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage. Cell Death Dis. 9;2:e171. 2011
  2. Sidler D, Renzulli P, Schnoz C, Berger B, Schneider-Jakob S, Flück C, Inderbitzin D, Corazza N, Candinas D, Brunner T. Colon cancer cells produce immunoregulatory glucocorticoids. Oncogene 30:2411-2419. 2011
  3. Schmich K, Schlatter R, Corazza N, Ferreira KS, Ederer M, Brunner T, Borner C, Merfort I. Tumor necrosis factor alpha sensitizes primary murine hepatocytes to Fas/CD95-mediated apoptosis in a Bim and Bid-dependent manner. Hepatology 53:282-292. 2011

Publications in 2010

  1. Schneider-Jakob S, CorazzaN, Badmann N, Sidler D, Stuber-Roos R, Frese S, Tschan M, Brunner T. Synergistic induction of cell death in liver tumor cells by TRAIL and chemotherapeutic drugs via the BH3-only proteins Bim and Bid. Cell Death Dis. 1, e86. 2010
  2. Noti M, Corazza N, Mueller C, Berger B, Brunner T. TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis. J Exp Med. 207(5):1057-66. 2010.
  3. Karamitopoulou E, Zlobec I, Tornillo L, Carafa V, Schaffner T, Brunner T, Borner M, Diamantis I, Zimmermann A, Terracciano L. Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). Pathology. 42(3):229-34. 2010
  4. Karamitopoulou E, Pallante P, Zlobec I, Tornillo L, Carafa V, Schaffner T, Borner M, Diamantis I, Esposito F, Brunner T, Zimmermann A, Federico A, Terracciano L, Fusco A. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Eur J Cancer. 46(8):1438-44. 2010
  5. Noti M, Corazza N, Tuffin G, Schoonjans K, Brunner T. Lipopolysaccharide induces intestinal glucocorticoid synthesis in a TNF alpha-dependent manner. FASEB J. 24(5):1340-6. 2010
  6. Karamitopoulou E, Rentsch CA, Markwalder R, Vallan C, Thalmann GN, Brunner T. Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. Pathology. 42(1):37-42. 2010
  7. Weinlich R, Brunner T, Amarante-Mendes GP. Control of death receptor ligand activity by posttranslational modifications. Cell Mol Life Sci. 67(10):1631-42. 2010

Publications in 2009

  1. Müller S, Rihs S, Schneider JM, Paredes BE, Seibold I, Brunner T, Mueller C. Soluble TNF-alpha but not transmembrane TNF-alpha sensitizes T cells for enhanced activation-induced cell death. Eur J Immunol. 39(11):3171-80. 2009
  2. Luckschander N, Pfammatter NS, Sidler D, Jakob S, Burgener IA, Moore PF, Zurbriggen A, Corazza N, Brunner T. Phenotyping, functional characterization, and developmental changes in canine intestinal intraepithelial lymphocytes. Vet Res. 40(6):58. 2009
  3. Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, Hasan L, Kappeler A, Brunner T, Vassella E. miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res. 69(13):5553-9. 2009
  4. Kassahn D, NachburU, ConusS, MicheauO, SchneiderS, SimonHU, Brunner T. Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells. Cell Death Diff. 16:115-24. 2009
  5. Corazza N, Kassahn D, Jakob S, Badmann A, Brunner T. TRAIL-induced apoptosis: between tumor therapy and immunopathology. Ann N Y Acad Sci. 1171:50-8. 2009
  6. Brunner, T. Living on the edge: immune cells and immunopathology in the intestinal mucosa. Sem. Immunopathol. 31(2):143-4. 2009. Guest Editor
  7. Noti, M, Sidler, D., and Brunner, T. Extra-adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? Sem. Immunopathol. 31(2):237-48. 2009

Publications in 2008

  1. Herold S, Steinmueller M, von Wulffen W, Cakarova L, Pinto R, Pleschka S, Mack M, Kuziel WA, Corazza N, Brunner T, Seeger W, Lohmeyer J. Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand.. J Exp Med. 2008. IF 15.612
  2. Kassahn D, Brunner T, Corazza N. Distinct but complementary roles of Fas ligand and Bim in homeostatic T cell apoptosis. Cell Cycle. 7(21). 2008. Co-senior author
  3. Karamitopoulou E, Tornillo L, Zlobec I, Cioccari L, Carafa V, Borner M, Schaffner T, Brunner T, Diamantis I, Zimmermann A, Terracciano L. Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. Am J Clin Pathol. 130:780-6. 2008.
  4. Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF. RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. J Virol. 82:12145-53. 2008.
  5. Didichenko SA, Spiegl N, Brunner T, Dahinden CA. IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood. 112:3949-58. 2008.
  6. Atanasov AG, Leiser D, Roesselet C, Noti M, Corazza N, Schoonjans K, Brunner T. Cell cycle-dependent regulation of extra-adrenal glucocorticoid synthesis in murine intestinal epithelial cells. FASEB J. 22:4117-25. 2008.
  7. Müller J, Sidler D, Nachbur U, Wastling J, Brunner T, Hemphill A. Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells. Int J Cancer. 123(8):1797-806. 2008.
  8. Jakob S, Corazza N, Diamantis E, Kappeler A, Brunner T. Detection of apoptosis in vivo using antibodies against caspase-induced neo-epitopes. Methods. 44:255-61. 2008.
  9. Mastino A, Basu S, Brunner T, Ricci JE, Diederich M. Long live the cell death! Cell Death Differ. 15:1330-2. 2008. IF 8.254
  10. Brumatti G, Yon M, Castro FA, Bueno-da-Silva AE, Jacysyn JF, Brunner T, Amarante-Mendes GP. Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide. Exp Cell Res. 314:554-63. 2008. IF 3.695

Publications in 2007

  1. Karamitopoulou-Diamantis, E., Cioccari, L., Jakob, S., Vallan, C., Schaffner, T., Zimmermann, A., and Brunner, T. Active caspase 3 and DNA fragmentation as markers for apoptotic cell death in primary and metastatic liver tumors. Pathology. 9:558-64. 2007
  2. Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, Corazza N, Antal MC, Metzger D, Desreumaux P, Brunner T, Auwerx J, Schoonjans K. LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease. Proc Natl Acad Sci U S A. 104:13098-103. 2007
  3. Plock J, Frese S, Keogh A, Bisch-Knaden S, Ayuni E, Corazza N, Weikert C, Jakob S, Erni D, Dufour JF, Brunner T, Candinas D, Stroka D. Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver. J Hepatol. 47:538-45. 2007. IF 6.642
  4. Mueller, M., Atanasov, A., Cima, I., Corazza, N., Schoonjans, K, and Brunner, T. Regulation of glucocorticoid synthesis in intestinal epithelial cells. Endocrinology. 48:1445-53. 2007

Publications in 2006

  1. Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T, and Simon HU. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 8:1124-32. 2006
  2. Cima, I., Fuhrer, A., and Brunner, T. Antagonistic and synergistic effects of glucocorticoids and IL-7 on CD4+ T cell activation. Immunol. Lett. 06:99-102. 2006
  3. Corazza, N., Jakob, S, Schaer, C., Frese, S, Keogh, A., Stroka, D., Mueller, C., Schneider, P., and Brunner T., TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest. 116:2493-9. 2006
  4. Mueller, M., Cima, I., Noti, M., Fuhrer, A., Jakob, S., Dubuquoy, L., Schoonjans, K, and Brunner, T. The nuclear orphan receptor LRH-1 critically regulates extra-adrenal glucocorticoid synthesis in the intestine. J. Exp. Med. 203:2057-62. 2006
  5. Nachbur, U., Kassahn, D., Yousefi, S., Legler, D.F. and Brunner, T. Postranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts. Blood. 107:2790-6. 2006
  6. Matter CM, Chadjichristos CE, Meier P, von Lukowicz T, Lohmann C, Schuler PK, Zhang D, Odermatt B, Hofmann E, Brunner T, Kwak BR, Luscher TF. Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis, inflammation, and neointima formation. Circulation. 113:1879-87. 2006
  7. Kassahn, D. Nachbur, U. and Brunner T. CD95L pro-drug: a novel Swiss Army Knife in cancer therapy? Cell Death Differ. 2006. 4:393-4

Publications in 2005

  1. Yada, S., Takamura, N., Inagaki-Ohara, K., O’leary, M.K., Wasem, C., Brunner, T., Green, D.R., Lin, T., Pinkoski, M.J. The role of p53 and Fas in a model of acute murine graft-versus-host disease. J. Immunol. 174:1291-1297. 2005

Publications in 2004

  1. Cima, I., Corazza, N., Dick, B., Fuhrer, A., Herren, S., Jakob, S., Ayuni, E., Mueller, C., Brunner, T. Intestinal epithelial cells synthesize glucocorticoids and regulate T cell activation. J. Exp. Med. 200:1635-1646. 2004
  2. Corazza, N., Brumatti, G., Jakob, S., Villunger, A. and Brunner, T. TRAIL and thymocyte apoptosis: not so deadly. Cell Death Differ. Suppl 2:S213-5. 2004
  3. Torgler, R., Jakob, S., Ontsouka, E., Nachbur, U., Mueller, C., Green, D.R., and Brunner, T. Regulation of activation-induced Fas (CD95/Apo-1) ligand expression in T cells by the cyclin B1/Cdc2 complex. J. Biol. Chem. 279:37334-37342. 2004
  4. Wiener, Z, Ontsouka, E., Wiener, Z., Jakob, S, Torgler, R., Falus, A., Mueller, C. and Brunner, T. Synergistic induction of the Fas ligand promoter in human lung cancer cells by Max and NFkB. Exp. Cell Res. 299:227-235. 2004
  5. Corazza, N., Brunner, T., Buri, C., Rihs, S., Imboden, M.A., Seibold, I., and Mueller, C. Transmembrane Tumor necrosis Factor is a potent inducer of colitis even in the absence of its secreted form. Gastroenterol. 127:816-825. 2004
  6. Engler, O.B., Schwendener, R.A., Dai, W.J., Wölk, B., Pichler, W., Moradpur, D., Brunner, T., and Cerny, A. A liposomal peptide vaccine inducing CD8+ T cells in HLA-A2.1 transgenic mice, which recognize human cells encoding hepatitis C virus (HCV) proteins. Vaccine. 23:58-68. 2004
  7. Brunner, T. and Martin, S.J. c-Myc: where death and division collide. Cell Cycle. 3:456-459. 2004
  8. Corazza, N. Brumatti, G., Schaer, C., Cima, I., Wasem, C., and Brunner, T. TRAIL and Immunity: more than a license to kill tumor cells. Cell Death Differ. Suppl. 2: S122-5. 2004

Publications in 2003

  1. Wasem, C., Arnold, D., Corazza, N., Saurer, L., Herren, C. Vallan, S., Mueller, C. and Brunner, T. Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. J. Clin. Invest. 111:1191-1199. 2003
  2. Cima, I. and Brunner, T. T cell apoptosis: about killers and victims. Biologist. 50:111-115. 2003.
  3. Brunner, T., Wasem, C., Torgler, R. Cima, I., Jakob, S., and Corazza, N. Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology. Seminars in Immunology. 15:167-176. 2003
  4. Brunner, T. and Mueller, C. Apoptosis in disease: about shortage and excess. Essays in Biochemistry. Portland Press, London. 39:119-30. 2003.

Publications in 2002

  1. Grogan, S.P., Aklin, B., Frenz, M., Brunner, T., Schaffner, T., and Mainil-Varlet, P. In vitro model for the study of necrosis and apoptosis in native cartilage. J. Pathol. 198:5-13. 2002
  2. Estaquier, J. Lelievre, J.D., Petit, F., Brunner, T., Moutouh-De Parseval, L., Richman, D.D., Ameisen, J.C., and Corbeil, J. Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death. J Virol. 76:5966-5973. 2002
  3. Arnold, D., Wasem, C., Juillard, S., Graber, P., Cima S., Frutschi, C., Herren, S., Jakob, S., Alouani, S., Mueller, C., Chvatchko, Y., and Brunner, T. IL-18-independent CTL activation and IFNg production during the pathogenesis of experimental acute graft-versus-host disease. Int. Immunol. 14:503-511. 2002
  4. Frese, S., Brunner, T., Gugger, M., Uduehi, A., Schmid, R.A. Apo2L/TRAIL-induced apoptosis in NSCLC cell lines is enhanced by chemotherapeutic agents but not correlated to the expression level of c-FLIP. J. Thorac Cardiov Sur. 123:168-174. 2002

Publications in 2001

  1. Daniel, C., Duffield, J., Brunner, T., Steinmann-Niggli, K., Lods, N., Marti, HP. Matrix metalloproteinase inhibitors cause cell cycle arrest and apoptosis in glomerular mesangial cells. J Pharmacol Exp Ther. 297:57-68. 2001
  2. Wasem, C., Frutschi, C., Arnold, D., Vallan, C., Lin, T., Green, D.R., Mueller, C, and Brunner, T. Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J. Immunol. 167:2936-2941. 2001
  3. Cefai, D. Schwaninger, R., Balli, M., Brunner, T., and Gimmi, C.D. Functional characterization of Fas ligand on tumor cells escaping active specific immunotherapy. Cell Death Diff. 8:687-695. 2001
  4. Brunner, T., Arnold, D., Wasem, C., Herren, S., and Frutschi, C. Regulation of cell death and survival in intestinal intraepithelial lymphocytes. Cell Death Diff. 8:706-714. 2001

Publications in 2000

  1. Kasibhatla, S., Beere, H.M., Brunner, T., Echeverri, F., and Green, D.R. A 'non-canonical' DNA-binding element mediates the response of the fas-ligand promoter to c-Myc. Curr Biol. 10:1205-1208. 2000
  2. Corazza, N., Müller, S., Brunner, T., Kägi, D., and Mueller, C. Differential contribution of Fas- and perforin-mediated pathways to the cell-mediated cytotoxic activity of ex vivo isolated, naive, and in vivo primed intestinal intraepithelial lymphocytes. J. Immunol. 164:398-403. 2000
  3. Pinkoski, M.J., Brunner, T., Green, D.R., and Lin, T. Fas and Fas ligand in the gut and liver. Amer. J. Physiol. Gastrointest. Liver Physiol. 278:G354-366. 2000.