Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell-cell-recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAMs have also been identified as receptors for host-specific viruses and bacteria in mice and humans, respectively, making these proteins an interesting example of pathogen-host co-evolution. Forward and reverse genetics in the mouse now provide powerful novel models to elucidate the action of CEACAM family members in vivo and we are taking full advantage of these exciting new opportunities.
Recent Publications:
Kuiper, J.W.P., Krause, J., Potgeter, L., Adrian, J., Hauck, C.R. 2023 A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis. J Cell Sci. 136(11). doi:10.1242/jcs.260771.
Goob, G., Adrian, J., Cossu, C., Hauck, C.R. 2022 Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ. J. Biol. Chem. 298(9): 102269. doi: 10.1016/j.jbc.2022.102269.
Muenzner, P., Hauck, C.R. 2020 Neisseria gonorrhoeae Blocks Epithelial Exfoliation by Nitric-Oxide-Mediated Metabolic Cross Talk to Promote Colonization in Mice. Cell Host Microbe 27(5): 793-808.e5. doi:10.1016/j.chom.2020.03.010.
Königer, V., Holsten, L., Harrison, U., Busch, B., Loell, E., Zhao, Q., Bonsor, D.A., Roth, A., Kengmo-Tchoupa, A., Smith, S.I., Mueller, S., Sundberg, E.J., Zimmermann, W., Fischer, W., Hauck, C.R., Haas, R. 2016 Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat Microbiol. 2: 16188. doi:10.1038/nmicrobiol.2016.188.
Adrian, J., Bonsignore, P., Hammer, S., Frickey, T., Hauck, C.R. 2019 Adaptation to host-specific bacterial pathogens drives rapid evolution of a human innate immune receptor. Current Biol. 29(4): 616-630 e5. doi:10.1016/j.cub.2019.01.058
Muenzner, P., Kengmo Tchoupa, A., Klauser, B., Brunner, T., Putze, J., Dobrindt, U., Hauck, C.R. 2016 Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa. PLoS Pathogens 12(5): e31005608.
Tchoupa, A.K., Lichtenegger, S., Reidl, J., Hauck, C.R. 2015 Outer membrane protein PI is the CEACAM-binding adhesin of Haemophilus influenzae. Mol. Microbiol. 98(3): 440-55.
Delgado Tascon, J., Adrian, J., Kopp, K., Scholz, P., Tschan, M.P., Kuespert, K., Hauck, C.R. 2015 The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. J. Leukoc. Biol. 97(3): 521-31.
Roth, A., Mattheis, C., Muenzner, P., Unemo, M., Hauck, C.R. 2013 Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections. Infection and Immunity 81(7): 2358-2370.
Kopp, K., Buntrun, A., Pils, S., Zimmermann, T., Frank, R., Zumbusch, A., Hauck, C.R. 2012 Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria. Journal of Biological Chemistry 287(46): 39158-70.
Voges, M., Bachmann, V., Naujoks, J., Kopp, K., Hauck, C.R., 2012 Extracellular IgC2 constant domains of CEACAMs mediate P13K sensitivity during uptake of pathogens. PLoS One 7(6): e39908.
Buntru, A., Roth, A., Nyffenegger-Jann, N.J., Hauck, C.R. 2012 The adaptor molecule Nck localizes the WAVE complex to promote actin polymerization during CEACAM3-miediated phagocytosis of bacteria. PLoS One 7(3): e32808.
Königer, V., Holsten, L., Harrison, U., Busch, B., Loell, E., Zhao, Q., Bonsor, D.A., Roth, A., Kengmo-Tchoupa, A., Smith, S.I., Mueller, S., Sundberg, E.J., Zimmermann, W., Fischer, W., Hauck, C.R., Haas, R. 2006 Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nature Microbiology 2: 16188.