Research and Publications
The Molecular Toxicology group seeks to understand how cells respond to genotoxic (DNA-damaging) stresses on a molecular, cellular, and organismic level and how these mechanisms contribute to (patho-)physiological states such as aging and cancer development. Build on this, we are interested in developing translational applications for disease prevention, diagnostics, and therapy.
Research projects focus on the topics:
I. Genetic Toxicology
II. DNA Damage and Repair
III. Poly(ADP-Ribosyl)ation
IV. Biomarkers of Aging
Featured Publications
- Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)
- Automated screening for oxidative or methylation-induced DNA damage in human cells. ALTEX. 2021.
- PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response. Nucleic Acids Res. 2020.
- The Nucleolus and PARP1 in Cancer Biology. Cancers (Basel). 2020.
- Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy. Nat Commun. 2020.
- NAD in sulfur mustard toxicity. Toxicol Lett. 2020.
- PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling. Scientific Reports. 2019.
- Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy. Nucleic Acids Res. 2019.
- A mass spectrometric platform for the quantitation of sulfur mustard-induced nucleic acid adducts as mechanistically relevant biomarkers of exposure. Arch Toxicol. 2019.
- Epigenetic and redox biomarkers: Novel insights from the MARK-AGE study. Mech Ageing Dev. 2019.
- The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1. Nucleic Acids Res. 2018.
- PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity. Arch Toxicol. 2018.
Full List of Publications
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