Publications Of FlowKon Users

Please report all publications that used the FlowKon resources. This is very important for grant applications and renewals. The publications can be reported via the PPMS booking software or by e-mail.

2019

Basler M, Claus M, Klawitter M, Goebel H, Groettrup M. Immunoproteasome Inhibition Selectively Kills Human CD14+ Monocytes and as a Result Dampens IL-23 Secretion. J Immunol October 1, 2019, 203 (7) 1776-1785; doi: 10.4049/jimmunol.1900182

Ganz M, Vogel C, Czada C, Jörke V, Gwosch EC, Kleiner R, Pierzynska-Mach A, Zanacchi FC, Diaspro A, Kappes F, Bürkle A, Ferrando-May E. The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. PLoS One 2019 Aug 13;14(8):e0213130. doi: 10.1371/journal.pone.0213130

Mah MM, Basler M, Groettrup M. The ubiquitin-like modifier FAT10 is required for normal IFN-γ production by activated CD8+ T cells. Mol Immunol. 2019 Apr;108:111-120. doi: 10.1016/j.molimm.2019.02.010.

Moreno-Villanueva M, Kramer A, Hammes T, Venegas-Carro M, Thumm P, Bürkle A, Gruber M. Influence of Acute Exercise on DNA Repair and PARP Activity before and after Irradiation in Lymphocytes from Trained and Untrained Individuals. Int J Mol Sci. 2019 Jun 19;20(12). pii: E2999. doi: 10.3390/ijms20122999.

Finke A, Schneider A-K, Spreng A-S, Leist M, Niemeyer CM, Marx A. Functionalized DNA Hydrogels Produced by Polymerase-Catalyzed Incorporation of Non-Natural Nucleotides as a Surface Coating for Cell Culture Applications. Adv Healthc Mater. 2019 May;8(9):e1900080. doi: 10.1002/adhm.201900080.

Szamosvári D, Schuhmacher T, Hauck CR, Böttcher T. A thiochromenone antibiotic derived from the Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis. Chem Sci. 2019 May 23;10(27):6624-6628. doi: 10.1039/c9sc01090d.

Baade T, Paone C, Baldrich A, Hauck CR. Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interaction. Sci Rep. 2019 Apr 5;9(1):5728. doi: 10.1038/s41598-019-42002-6.

Adrian J, Bonsignore P, Hammer S, Frickey T, Hauck CR. Adaptation to Host-Specific Bacterial Pathogens Drives Rapid Evolution of a Human Innate Immune Receptor. Current Biology. doi: 10.1016/j.cub.2019.01.058

Li J, Koerner J, Basler M, Brunner T, Kirk CJ, Groettrup M. Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors. Kidney Int. 2019 Mar;95(3):611-623. doi: 10.1016/j.kint.2018.10.022

2018

Schregle R, Mah MM, Mueller S, Aichem A, Basler M, Groettrup M. The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions. Immunogenetics. doi: 10.1007/s00251-018-1055-5

Schmidt C, Berger T, Groettrup M, Basler M. Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis. Front Immunol. doi: 10.3389/fimmu.2018.02386.

Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Langrish CL, Groettrup M. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. doi: 10.15252/embr.201846512

Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, Groettrup M. Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation. Kidney international. doi: 10.1016/j.kint.2017.09.023

Fischbach A, Krüger A, Hampp S, Assmann G, Rank L, Hufnagel M, Stöckl MT, Fischer JMF, Veith S, Rossatti P, Ganz M, Ferrando-May E, Hartwig A, Hauser K, Wiesmüller L, Bürkle A, Mangerich A. The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1. Nucleic Acids Res. 2018 Jan 25;46(2):804-822. doi: 10.1093/nar/gkx1205

Fischer JMF, Zubel T, Jander K, Fix J, Trussina IREA, Gebhard D, Bergemann J, Bürkle A, Mangerich A. PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity. A´rch Toxicol. 2018 Mar;92(3):1323-1340. doi: 10.1007/s00204-017-2115-6.

Basler M, Mundt S, Groettrup M. The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. Eur J Immunol. 2018 Mar;48(3):419-429. doi: 10.1002/eji.201747282.

2017

Nyffeler J, Chovancova P, Dolde X, Holzer AK, Purvanov V, Kindinger I, Kerins A, Higton D, Silvester S, van Vugt-Lussenburg BMA, Glaab E, van der Burg B, Maclennan R, Legler DF, Leist M. A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins. Arch Toxicol (2018) 92: 1225. doi: 10.1007/s00204-017-2125-4

Nyffeller J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M. Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol. doi: 10.1007/s00204-017-1977-y.

Pallocca G, Nyffeller J, Dolde X, Grinberg M, Gstraunthaler G, Waldmann T, Rahnenführer J, Sachinidis A, Leist M. Impairment of human neural crest cell migration by prolonged exposure to interferon-beta. Arch Toxicol. doi: 10.1007/s00204-017-1966-1. 

Sommershof A, Scheuermann L, Koerner J, Groettrup M. Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma. Brain Behav Immun. doi: 10.1016/j.bbi.2017.04.021.

Basler M, Maurits M, DeBruin G, Koerner J, Overkleeft HS, Groettrup M. Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome. BrJ Pharmacol. doi: 10.1111/bph.14069

2016

Königer V, Holsten L, Harrison U, Busch B, Loell E, Zhao Q, Bonsor DA, Roth A, Kengmo-Tchoupa A, Smith SI, Mueller S, Sundberg EJ, Zimmermann W, Fischer W, Hauck CR, Haas R. Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA. Nat Microbiol. doi: 10.1038/nmicrobiol.2016.233

Rank L, Veith S, Gwosch EC, Demgenski J, Ganz M, Jongmans MC, Vogel C, Fischbach A, Buerger S, Fischer JM, Zubel T, Stier A, Renner C, Schmalz M, Beneke S, Groettrup M, Kuiper RP0, Bürkle A, Ferrando-May E, and Mangerich A. Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. Nucleic Acids Res. doi: 10.1093/nar/gkw859.

Felletti M, Stifel J, Wurmthaler LA, Geiger S, Hartig JS. Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nat commun. doi: 10.1038/ncomms12834.

Chu L, Ewe D, Río Bártulos C, Kroth PG, and Gruber A. Rapid induction of a GFP espressin by the nitrate reductase promotor in the diatom of Phaeodactylum tricornutum. PeerJ. doi:10.7717/peerj.2344.

Nyffeler J, Karreman C, Leisner M, Kim YJ, Lee G, Waldmann T, and Leist M. Design of a high throughput human neural crest cell migration assay to indicate potential developmental toxicants. Altex. doi: 10.14573/altex.1605031.

Buntz A, Wallrodt S, Gwosch E, Schmalz M, Beneke S, Ferrando-May E, Marx A, and Zumbusch A. Real-time Cellular Imaging of Protein Poly(ADP-ribos)ylation. Angewandte Chemie International Edition. doi: 10.1002/ani.201605282

Späte AK, Dold JE, Batroff E, Schart VF, Wieland DE, Baudendistel OR, and Wittmann V. Exploring the potential of Norbornene-modified mannosamine derivatives for metabolic glycoengineering. ChemBioChem. doi: 10.1002/cbic.201600197.

Muenzner P, Kengmo Tchoupa A, Klauser B, Brunner T, Putze J, Dobrindt U, and Hauck CR. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa. PLoS Pathog. doi: 10.1371/journal.ppat.1005608.

Paone C, Rodrigues N, Ittner E, Santos C, Buntru A, Hauck C.R. The tyrosine kinase Pyk2 contributes to complement-mediated phagocytosis in murine macrophages. Journal of Innate Immunity. doi:10.1159/000442944.

Mundt S, Basler M, Buerger S, Engler H, and Groettrup M. Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice. Scientific Reports. doi: 10.1038/srep19434.

Doll F, Buntz A, Späte AK, Schart VF, Timper A, Schrimpf W, Hauck CR, Zumbusch A, Wittmann V. Visualization of Protein-Specific Glycosylation inside Living Cells. Angew Chem Int Ed Engl. doi: 10.1002/anie.201503183

Mundt S, Engelhardt B, Kirk CJ, Groettrup M, Basler M. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.Eur J Immunol. 2016 Jan;46(1):104-13. doi: 10.1002/eji.201545578.

2015

Delgado Tascón J, Adrian J, Kopp K, Scholz P, Tschan MP, Kuespert K, Hauck CR. The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. J Leukoc Biol. doi: 10.1189/jlb.2AB0813-449RR

Herrmann VL, Wieland DE, Legler DF, Wittmann V, and Groettrup M. The STEAP1 262-270 Peptide Encapsulated into PLGA Microspheres Elicits Strong Cytotoxic T Cell Immunity in HLA-A*0201 Transgenic Mice – a New Approach to Immunotherapy against Prostate Carcinoma. Prostate. doi: 10.1002/pros.23136.

Mundt S, Engelhardt B, Kirk CJ, Groettrup M, and Basler M. Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. European Journal of Immunology. doi: 10.1002/eji.201545578.

Buerger S, Herrmann VL, Mundt S, Trautwein N, Groettrup M, and Basler M. The Ubiquitin-like modifier FAT10 is selectively expressed in medullary thymic epithelial cells and modifies T cell selection. Journal of Immunology. doi: 10.4049/jimmunol.1500592.

Herrmann VL, Hartmayer C, Planz O, and Groettrup M. Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease. Journal of Controlled Release. doi: 10.1016/j.jconrel.2015.08.019.

Tchoupa AK, Lichtenegger S, Reidl J, Hauck CR. Outer membrane protein P1 is the CEACAM-binding adhesin of Haemophilus influenzae. Molecular Microbiology. doi: 10.1111/mmi.13134.

2014

Benjamin Hanf. Assessment of unique and combined functions of poly(ADP-ribose) polymerases by using RNA interference. Dissertation. Chair of Molecular Toxicology, Department of Biology, University of Konstanz, November 2014.

Deutzmann A, Ganz M, Schönenberger F, Vervoorts J, Kappes F, and Ferrando-May E. The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. Oncogenedoi: 10.1038/onc.2014.346.

Marcia Maier. Preparation and characterization of DAAO-overexpressing renal cells for the investigation of propiverine-induced effects. Master's Thesis. Chair of Human and Environmental Toxicology, Department of Biology, University of Konstanz, March 2014.