04.09.2020 - New publications

Pawar, A., Basler, M., Goebel, H., Alvarez Salinas, G. O., Groettrup, M., and Bottcher, T. (2020) Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome. ACS Cent. Sci. 6: 241-246. Doi: 10.1021/acscentsci.9b01170 PMID: 32123742

Aichem, A., and Groettrup, M. (2020) The ubiquitin-like modifier FAT10 - much more than a proteasome-targeting signal. J. Cell Sci. 133 doi: 10.1242/jcs.246041 PMID: 32719056

Held, T., Basler, M., Knobeloch, K. P., and Groettrup, M. (2020) Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation. Eur. J. Immunol.  doi: 10.1002/eji.202048646. PMID: 32686110

Mah, M. M., Roverato, N., and Groettrup, M. (2020) Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10. Biomolecules 10 doi: 10.3390/biom10060951 PMID: 32586037

Schregle, R., Mueller, S., Legler, D. F., Rossy, J., Krueger, W. A., and Groettrup, M. (2020) FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly. J. Cell Sci. 133 doi: 10.1242/jcs.240085 PMID: 32546531

Basler, M., and Groettrup, M. (2020) Recent insights how combined inhibition of immuno/proteasome subunits enables therapeutic efficacy. Genes Immunity doi: 10.1038/s41435-020-00109-1 PMID: 32839530

Boehm, A. N., Bialas, J., Catone, N., Sacristan-Reviriego, A., van der Spuy, J., Groettrup, M., and Aichem, A. (2020) The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation. J. Biol. Chem. doi: 10.1074/jbc.RA120.013873 PMID: 32817338

30.09.2019 - New publications

Aichem, A., Sailer, C., Ryu, S., Catone, N., Stankovic-Valentin, N., Schmidtke, G., Melchior, F., Stengel, F., and Groettrup, M. (2019) The ubiquitin-like modifier FAT10 interferes with SUMO activation. Nat. Commun. 10: 4452. doi: 10.1038/s41467-019-12430-z. PMID: 31575873

Basler M, Claus M, Klawitter M, Goebel H, Groettrup M. (2019) Immunoproteasome Inhibition Selectively Kills Human CD14(+) Monocytes and as a Result Dampens IL-23 Secretion. J Immunol. 203: 1776-1785. doi:10.4049/jimmunol.1900182. PMID: 31484727.

Basler M, Groettrup M. (2019) Testing the Impact of Protease Inhibitors in Antigen Presentation Assays. Methods Mol Biol. 1988: 59-69. doi: 10.1007/978-1-4939-9450-2_5. PMID: 31147932.

Koerner J, Horvath D, Groettrup M. (2019) Harnessing Dendritic Cells for Poly (D,L-lactide-co-glycolide) Microspheres (PLGA MS)-Mediated Anti-tumor Therapy. Front Immunol. 10: 707. doi: 10.3389/fimmu.2019.00707. PMID: 31024545.

Aichem A, Boehm AN, Catone N, Schmidtke G, Groettrup M. (2019) Analysis of modification and proteolytic targeting by the ubiquitin-like modifier FAT10. Methods Enzymol. 618: 229-256. doi: 10.1016/bs.mie.2018.12.040. PMID: 30850054.

13.02.2019 - New publications

Bialas, J., Boehm, A., Catone, N., Aichem, A., and Groettrup, M. (2019) The ubiquitin-like modifier FAT10 stimulates the activity of the deubiquitylating enzyme OTUB1. J. Biol. Chem. 294: 4315-4330.  doi: 10.1074/jbc.RA118.005406.  PMID: 30718280

Mah, M. M., Basler, M., and Groettrup, M. (2019) The ubiquitin-like modifier FAT10 is required for normal IFN-γ production by activated CD8+ T cells Mol. Immunol. 108: 111-120. DOI: 10.1016/j.molimm.2019.02.010  PMID: 30818228

12.10.2018 - New publications

Schmidt, C., Berger, T., Groettrup, M., and Basler, M. (2018) Immunoproteasome inhibition impairs T and B cell activation by restraining ERK signaling and proteostasis. Front. Immunol. 9:2386. PMID: 30416500

Li, J., Koerner, J., Basler, M., Brunner, T., Kirk, C. J., and Groettrup, M. (2018) How immunoproteasome inhibition interferes with plasma cell expansion to preserve kidney allografts. Kidney Int. 95(3):611-623. PMID: 30685098

Gutbier, S., Spreng, A.-S., Delp, J., Schildknecht, S., Karreman, C., Suciu, I., Brunner, T., Groettrup, M., and Leist, M. (2018) Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress. Cell Death Differentiation, 25(12):2101-2117. PMID: 30390092

18.09.2018 - New publication

Basler, M., Lindstrom, M. M., LaStant, J. J., Bradshaw, J. M., Owens, T. D., Schmidt, C., Maurits, E., Tsu, C., Overkleeft, H. S., Kirk, C. J., Langrish, C. L., and Groettrup, M. (2018) Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO reports 19(12): e46512. PMID: 30279279

Basler M, Li J, Groettrup M. (2019) On the role of the immunoproteasome in transplant rejection. Immunogenetics  71(3): 263-271. doi: 10.1007/s00251-018-1084-0.  PMID: 30220008.

03.07.2018 - New publication

Aichem, A., Anders, S., Catone, N., Rößler, P., Stotz, S., Berg, A., SchwabR., Scheuermann, S., Bialas, J., Schütz-Stoffregen, M. C., Schmidtke, G., Peter, C., Groettrup, M., and Wiesner, S. (2018) The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat. Commun. 9(1): 3321. doi: 10.1038/s41467-018-05776-3.  PMID: 30127414

06.04.2018 - New publication

Treise, I., Huber, E. M., Klein-Rodewald, T., Heinemeyer, W., Grassmann, S. A., Basler, M., Adler, T., Rathkolb, B., Helming, L., Andres, C., Klaften, M., Landbrecht, C., Wieland, T., Strom, T. M., McCoy, K. D., Macpherson, A. J., Wolf, E., Groettrup, M., Ollert, M., Neff, F., Gailus-Durner, V., Fuchs, H., Hrabě de Angelis, M., and Groll, M., Busch, D. H. . (2018) Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. Sci. Rep. 8(1): 5975. PMID: 29654304

21.02.2018 - New publication

Schregle, R., Mah, M. M., Mueller, S., Aichem, A., Basler, M., and Groettrup, M. (2018) The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions. Immunogenetics, 70(7): 429-438. PMID: 29508036

15.12.2017 - New publications

Schmidtke G, Schregle R, Alvarez G, Huber EM, Groettrup M. The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10. Mol Immunol. 2017 Dec 2. pii: S0161-5890(17)30593-X. doi: 10.1016/j.molimm.2017.11.030. PMID: 29208314

Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, Groettrup M. (2018) Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation. Kidney Int. 93(3): 670-680. doi: 10.1016/j.kint.2017.09.023. PMID: 29229189

02.11.2017 - New publication

Basler, M., Mundt, S., and Groettrup, M. (2017) The immunoproteasome subunit LMP7 is required in the thymus for filling up a hole in the T cell repertoire. Eur. J. Immunol. 48(3): 419-429. PMID: 29067678

28.09.2017 - New publication

Basler, M., Maurits, E., de Bruin, G., Koerner, J., Overkleeft, H. S., and Groettrup, M. (2017) Amelioration of autoimmunity with an inhibitor selectively targeting all active centers of the immunoproteasome. Br. J. Pharmacol. 175(1):38-52. doi: 10.1111/bph.14069 PMID: 29034459

27.07.2017 - Best Paper Award for Julia Körner

Today our group member Julia Körner, PhD student since 2014, was awarded the Best Paper Award for the first half of 2017 by the Department of Biology. Her recently published first-author study "Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice" (Oncotarget, 2017 Feb 7) was chosen as one of the three best peer-review publications by members of the Department of Biology.  In her PhD-project study Julia was able to identify the immunoproteasome as a novel drug target for the treatment of inflammation-driven colon cancers in three different pre-clinical models and both in preventive and in therapeutic settings. Our group gladly congratulates Julia and all co-workers.