Publications / Articles

Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F blocks cancer cell invasion.

Grimm, T.M., Herbinger, M., Krüger, L., Müller, S., Mayer, T.U., Hauck C.R. (2022) Cell Chemical Biology (2022) 16. Juni 2022; online veröffentlicht am 19. April 2022.
doi.org/10.1016/j.chembiol.2022.03.011 


Identification of small molecule activators of the ubiquitin ligase E6AP/UBE3A and Angelman syndrome-derived E6AP/UBE3A variants

Offensperger F, Müller F, Jansen J, Hammler D, Götz KH, Marx A, Sirois CL, Chamberlain SJ, Stengel F, Scheffner M (2020). Cell Chem Biol 27, 1510-1520, PMID: 32966807

Identification of Bioactive Small Molecule Inhibitors of Separase

Lars Henschke, Matthias Frese, Susanne Hellmuth, Andreas Marx, Olaf Stemmann, Thomas U. Mayer
ACS Chem. Biol. 2019, 14, 10, 2155-2159 Publication Date: September 25, 2019, Article ASAPDOI: 10.1021/acschembio.9b00661

Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis

Kathrin H. Götz, Stephan M. Hacker, Daniel Mayer, Jan-Niklas Dürig, Steffen Stenger and Andreas Marx
ACS Chem. Biol., Article ASAPDOI: 10.1021/acschembio.7b00653, September 2017, PMID:28892605

Small molecule inhibitors of the tumor suppressor Fhit

Sandra Lange, Stephan Hacker, Philipp Schmid, Martin Scheffner, Andreas MarxChemBioChem 10.1002/cbic.201700226, PMID:28643453

Ribosome Assembly as Antimicrobial Target

Nikolay R., Schmidt S., Schlömer R., Deuerling E., Nierhaus KH.
Antibiotics (Basel). 2016 May 27;5(2). pii: E18. doi: 10.3390/antibiotics5020018
PMCID: PMC4929433

A semi-automated, KNIME-based workflow for biofilm assays BMC Microbiology

Leinweber, Katrin; Müller, Silke; Kroth, Peter G. (2016): A semi-automated, KNIME-based workflow for biofilm assays BMC Microbiology ; 16 (2016). - 61. - eISSN 1471-2180

Nanoliter liquid transfers aid search for new antibiotics

Nanoliter liquid transfers aid search for new antibiotics (Tecan journal 1/2015) "Validation of a fluorescence-based screening concept to identify ribosome assembly defects in Escherichia coli"

Rainer Nikolay, Renate Schloemer, Sabine Schmidt, Silke Mueller, Anja Heubach, Elke Deuerling
Nucleic Acids Res. 2014 August 1; 42(12): e100. Published online 2014 May 9. doi: 10.1093/nar/gku381 PMCID: PMC4081057

Fluorescence-based monitoring of ribosome assembly landscapes

"Fluorescence-based monitoring of ribosome assembly landscapes"
Rainer Nikolay, Renate Schloemer, Silke Mueller, Elke Deuerling
BMC Mol Biol. 2015; 16: 3. Published online 2015 February 25. doi: 10.1186/s12867-015-0031-y PMCID: PMC4344731

Mad2 Inhibitor-1 (M2I-1)

"Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint."
Kastl J, Braun J, Prestel A, Möller HM, Huhn T, Mayer TU
ACS Chem Biol. 2015 Jul 17;10(7):1661-6. doi: 10.1021/acschembio.5b00121. Epub 2015 May 15. PMID:25978000

Validation of a fluorescence-based screening concept to identify ribosome assembly defects in Escherichia coli

Nikolay R., Schloemer R., Schmidt S., Mueller S., Heubach A., Deuerling E.
Nucleic Acids Res. 2014 Jul;42(12):e100. doi: 10.1093/nar/gku381. Epub 2014 May 3.

Expanding the scope of Human DNA Polymerase λ and b Inhibitors

T. Strittmatter, A. Brockmann, M. Pott, A. Hantusch, T. Brunner, A. Marx
ACS Chem. Biol. 2014, 9, 282-290.

Novel Fluorogenic ATP Analogues for Online Monitoring of  ATP Consumption: Observing Ubiquitin Activation in Real-Time

S. M. Hacker, D. Pagliarini, T. Tischer, N. Hardt, D. Schneider, M. Mex, T. U. Mayer, M. Scheffner, A. Marx
Angew. Chem. Int. Ed. 2013, 52, 11916-9.

Small Molecule Inhibitors of Human DNA Polymerase λ

T. Strittmatter, B. Bareth, T. A. Immel, T. Huhn, T. U. Mayer, A. Marx
ACS Chem. Biol. 2011, 6, 314-319