Scientific reviews

Besides experimental research, we also conceptualize new toxicological approaches within the transatlantic think tank for toxicology (t4), and we are strongly involved in promoting research and development in the field of alternative methods to animal experimentation, within our joint venture of CAAT-Europe in Konstanz and CAAT at the Bloomberg School of Public Health at Johns-Hopkins University in Baltimore (ref. 3-10). Other conceptual work is done with EFSA or the OECD (ref. 1, 2)

Example references:

  1. Fritsche E, Crofton KM, Hernandez AF, Hougaard Bennekou S, Leist M, Bal-Price A, Reaves E, Wilks MF, Terron A, Solecki R, Sachana M, Gourmelon A (2017) OECD/EFSA workshop on developmental neurotoxicity (dnt): the use of non-animal test methods for regulatory purposes.           
    ALTEX, 34, 167-171. doi: 10.14573/altex.1701171
  2. Ockleford C, Adriaanse P, Berny P, Brock T, Duquesne S, Grilli S, Hernandez-Jerez AF, Bennekou SH, Klein M, Kuhl T, Laskowski R, Machera K, Pelkonen O, Pieper S, Smith R, Stemmer M, Sundh I, Teodorovic I, Tiktak A, Topping CJ, Wolterink G, Angeli K, Fritsche E, Hernandez-Jerez AF, Leist M, Mantovani A, Menendez P, Pelkonen O, Price A, Viviani B, Chiusolo A, Ruffo F, Terron A and Bennekou SH (EFSA Panel on Plant Protection Products and their Residues) (2017). Scientific Opinion on the investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson’s disease and childhood leukaemia.     
    EFSA J 15, 4691, (325 pages) doi:10.2903/j.efsa.2017.4691
  3. Pamies D, Bal-Price A, Simeonov A, Tagle D, Allen D, Gerhold D, Yin D, Pistollato F, Inutsuka T, Sullivan K, Stacey G, Salem H, Leist M, Daneshian M, Vemuri MC, McFarland R, Coecke S, Fitzpatrick SC, Lakshmipathy U, Mack A, Wang WB, Yamazaki D, Sekino Y, Kanda Y, Smirnova L, Hartung T. (2017) Good Cell Culture Practice for stem cells and stem-cell-derived models.           
    ALTEX 34, 95-132
  4. Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, S Tsyb, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A (2016) Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing using animals.    
    ALTEX 33, 272-321
  5. Sauer JM, Hartung T, Leist M, Knudsen TB, Hoengg J, Hayes W (2015) Systems toxicology: the future of risk assessment   
    Int J Toxicol 34, 346-348
  6. Daneshian M, Busquet F, Hartung T, Leist M. (2015) Animal use for science in Europe. ALTEX 32, 261-274.
  7. Bal-Price A, Crofton K, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald R, Hartung T, Heinonen T, Hogberg H, Hougaard S, Lichtensteiger W, Oggier D, Paparella M, Axelstad Petersen M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Tschudi-Monnet F, Wilks M, Ylikomi T, Fritsche E (2015) International STakeholder NETwork for Developmental Neurotoxicity (ISTNET): Creating a Developmental Neurotoxicity (DNT) Testing Roadmap for regulatory purposes  
    Arch Toxicol 89, 269-287
  8. van Vliet E, Daneshian M, Beilmann M, Davies A, Fava E, Fleck R, Julé Y, Kansy M, Kustermann S, Macko P, Mundy W, Roth A, Sachse C, Shah I, Uteng M, van de Water B, Hartung T, Leist M (2014) Current approaches and future role of high content imaging in safety sciences and drug discovery.       
    ALTEX 31, 479-493
  9. Alépée N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K and Zurich MG. (2014) State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology        
    ALTEX 31, 441-477
  10. Leist M, Hasiwa N, Rovida C, Daneshian M, , Basketter D, Kimber I, Clewell H, Gocht T, Goldberg A, Busquet F, Rossi AM, Schwarz M, Stephens M, Taalman R, Knudsen TB, McKim J, Harris G, Pamies D, Hartung T (2014) Consensus report on the future of animal-free systemic toxicity testing    
    ALTEX, 31, 341-356